Solventfree Sonogashira coupling reaction via high speed ...
Herein, we report on the solventfree Sonogashira reaction utilizing high speed ball milling. Sonogashira coupling of a variety of para substituted aryl halides were performed with trimethylsilylacetylene or observed that iodo and bromo substituted aromatics successfully undergo Sonogashira, chloro and fluoro substituted aryl compounds .